[英文釋義] Large,transmembrane,non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice,two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes,macrophages,epidermal cells,and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse,but is now used as a generic term for any class II histocompatibility antigen.
As c ii ta is a single gene or protein that affects a large family of genes, it represents an ideal target for intervention in the class ii antigen presentation pathway, for immune suppression in transplantation and autoimmumty 作為影響一個大基因家族的單個基因或蛋白質(zhì),cta是對mhc-類的抗原提呈過程進(jìn)行干預(yù)的理想靶點,可以在自身免疫損傷和移植排異過程中進(jìn)行免疫抑制干預(yù)。